Our Biofunctional Nanomaterials group research the design and development of self-assembling nanostructures/platforms for biomedical applications based on the building blocks of life, namely peptide and their unnatural variants (peptide-mimetics).
These structures have the ability to form nanofibrous hydrogels or nanotubular structures with high surface to volume ratios in the presence of specific physiological stimuli (e.g. pH, temperature, enzymes). They have huge potential within the fields of drug delivery and biomaterials with the group’s focus primarily on the development of antimicrobial and anticancer technologies, sustained release drug delivery systems (injectable implants) and molecules with the ability to transverse the biological barriers (e.g. blood-brain barrier, outer membrane of Gram-negative bacteria).
Our most recent work relates to the development of self-assembling peptide-based hydrogel materials for use against infection and as long releasing implants for diseases with medication adherence issues (e.g. HIV/AIDs).
Harnessing a “bottom-up” approach, variation of the primary amino acid sequence of peptides allows structures to spontaneously assemble into ordered nanostructures upon exposure to varying environmental factors/stimuli. The peptide backbone provides a unique primer for tailoring biocompatibility, biodegradability and functionality.
We have interest in developing these technologies with the ultimate goal of translating them into healthcare products for patient benefit, working closely with our academic partners, funding agencies, charities, industry, clinicians and the public.
PhD positions available within our group: 7th January 2019 deadline
07 December, 2018
A number of PhD positions are available within the group. Funding will be allocated to successful applicants rather, than project. Successful applicant will receive tuition fees(UK/EU) paid and a stipend (for UK residents only). Closing date for all applications is 7th January 2019 with interviews being scheduled for February 2019. Dr Garry Laverty (First […]
Our book, Hydrogels: Design, synthesis & application in drug delivery & regenerative medicine, available now!
01 October, 2018
If you are interested in knowing more about the potential applications of our hydrogels, remember to check out our recent book “Hydrogels: Design, synthesis & application in drug delivery & regenerative medicine,” co-edited alongside Dr Raj Thakur and Prof Ryan Donnelly. Thanks to all those who contributed.
Summer Studentships 2019
18 January, 2019
There are two positions for an 8 week undergraduate summer studentship in our lab this year. The positions are dependent on successful funding from either the Wellcome Trust and/or Society for Applied Microbiology. The deadline for application to both these funders is the 14th February, so if you are interested email us (email@example.com) letting me […]