Original Research Publications

Coulter, S.M., Pentlavalli, S., An, Y., Vora, L., Cross, E.R, Moore, J., Sun, H., Schweins, R., McCarthy, H.O., Laverty, G.* In situ forming, enzyme-responsive peptoid-peptide hydrogels: An advanced long-acting injectable drug delivery system. Journal of the American Chemical Society. 2024. Accepted, in press.

Ghosh, D., Coulter, S.M., Laverty, G., Holland, C., Doutch, J.J., Vassalli, M., Adams, D.J.* Metal cross-linked supramolecular gel noodles: Structural insights and antibacterial assessment. Biomacromolecules 2024, 25, 5, 3169–3177.

Zhao X., Boyd P., Bashi Y.D., Murphy D.J., McCoy C.F., Coulter S.M., Laverty G., Malcolm R.K. Two into one does go: Formulation development of a multipurpose combination vaginal ring releasing dapivirine and metronidazole for prevention of HIV infection and treatment of bacterial vaginosis. International Journal of Pharmaceutics. 2023 Nov 4;648:123572.

Coulter, S.M., Pentlavalli, S., An, Y., Cross, E.R., Vora, L., Peng, K., McAulay, K., Schweins, R., McCarthy, H.O., Donnelly, R., Laverty, G.* (2023) Enzyme triggered L-α/D-peptide hydrogels as a long-acting injectable delivery platform for HIV/AIDS. Advanced Healthcare Materials. 2203198

Gade, S., Mishra, D., Pentlavalli, S., Vora, L., Waite, D., Laverty, G., Larrañeta, E., Donnelly, R. & Singh, T. R. R.* (2022) Injectable depot forming thermoresponsive hydrogel for sustained intrascleral delivery of sunitinib using hollow microneedles. Journal of Ocular Pharmacology and Therapeutics. 8(6):433-448. DOI: 10.1089/jop.2022.0016.

Afami, M.E.; El Karim, I.; About, I.; Krasnodembskaya, A.D.; Laverty, G.; Lundy, F.T.* (2021) Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp. Pharmaceutics. 13, 1575.

Albadr, A.A., Tekko, I.A., Vora, L.K., Ali, A.A., Laverty, G., Donnelly, R.F., Raghu Thakur, R.S* (2021) Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections. Drug Delivery and Translational Research.

Afami, M.E.; El Karim, I.; About, I.; Coulter, S.M.; Laverty, G.; Lundy, F.T* (2021) Ultrashort Peptide Hydrogels Display Antimicrobial Activity and Enhance Angiogenic Growth Factor Release by Dental Pulp Stem/Stromal Cells. Materials, 14, 2237. https://doi.org/10.3390/ma14092237

Huwaitat, R., Coulter, S.M., Porter, S.L., Pentlavalli, S., Laverty, G* (2021) Antibacterial and antibiofilm efficacy of synthetic polymyxin-mimetic lipopeptides. Peptide Science. 113:e24188.

Cross, E.R., Coulter, S.M., Fuentes-Caparrós, A.M., McAulay, K., Schweins, R., Laverty, G.,* Adams, D.J.* (2020) Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation. Chemical Communications. 6, 8135-8138. DOI: 10.1039/d0cc02569k

Porter, S.L., Coulter, S.M., Pentlavalli, S., & Laverty, G.* (2020). Pharmaceutical formulation and characterization of dipeptide nanotubes for drug delivery applications. Macromolecular Bioscience. 20, 2000115

Tethera, A.L., Laverty, G., Pugac, A.V., Seddon, K.R., Gilmore, B.F., Kelly, S.A.* High-throughput toxicity screening of novel azepanium and 3-methylpiperidinium ionic liquids. RSC Advances. 10, 22864-22870

McCloskey,A.P., Lee,M., Megaw,J., McElroy,J., Gilmore,S.M., Pentlavalli,S., Laverty,G.* (2019). Investigating the in vivo antimicrobial activity of a self-assembling peptide hydrogel using a Galleria mellonella infection model. ACS Omega 2019, 4, 2, 2584-2589

Porter,S.P., Coulter,S.M., Pentlavalli,S., Thompson,T.P., Laverty,G.* (2018). Self-assembling diphenylalanine peptide nanotubes selectively eradicate bacterial biofilm infection. Acta Biomaterialia. 77: 96-105

Laverty,G.,* Belaid,L., Coulter,C., Porter,S.L. (2018). Development of a teaching model to advance skills in industrial pharmaceutical formulation and regulatory aspects. Currents in Pharmacy Teaching and Learning. 10 (10): 1419-1428.

Albadr,A., Gilmore,S.M., Porter,S., Thakur,R., Laverty,G.* (2018). Ultrashort self-assembling peptide hydrogel for the treatment of fungal infections. Gels. 4(2), 48.

Laverty,G. (2018) Peptide nanomaterials as future antimicrobial technologies. Future Microbiology. 13(1), 5-7.

Brady,A.J., Laverty,G., Gilpin,D.F., Kearney,P., Tunney,M. (2017) Antibiotic Susceptibility of Planktonic and Biofilm Grown Staphylococci Isolated from Implant Associated Infections: Should MBEC and Nature of Biofilm Formation Replace MIC? Journal of Medical Microbiology. 66, 461–469

McCloskey,A.P., Draper,E.R., Gilmore, B.F., Laverty,G.* (2017). Ultrashort self-assembling Fmoc-peptide gelators for anti-infective biomaterial applications.Journal of Peptide Science. 23, 2, 131–140.

McCloskey,A.P., Gilmore,S.M., Zhou,J., Draper,E.R., Porter,S., Gilmore, B.F., Xu,B., Laverty,G.* (2016) Self-assembling Ultrashort NSAID-Peptide Nanosponges: Multifunctional Antimicrobial and Anti-inflammatory Materials. RSC Advances. 6, 114738-114749.

Flynn,P., Bussetti,A., Wielognorska,E., Chevallier,O., Elliot,C., Laverty,G., Gorman,S.P., Graham,W., *Gilmore,B.F (2016). Non-thermal Plasma Exposure Rapidly Attenuates Bacterial AHL-Dependent Quorum Sensing and Virulence. Nature Scientific Reports. 6, 26320​.

*Laverty,G., McCloskey,A.P., Gorman,S.P., Gilmore,B.F (2015). Antibiofilm activity of ultrashort cinnamic acid peptide derivatives against medical device related pathogens. Journal of Peptide Science. DOI: 10.1002/psc.2805. 21(10): 770-778

Chatta,D., Cottrell,L., Burnett,B., Laverty,G., *McConville,C (2015). The use of water soluble mucoadhesive gels for the intravesical delivery of epirubicin to the bladder for the treatment of non-muscle invasive bladder cancer. Journal of Pharmacy and Pharmacology. DOI: 10.1111/jphp.12441. 67(10):1355-62

Laverty,G., Hanna,L.A., Haughey,S. and Hughes,C. (2015). Developing Entrepreneurial skills in Pharmacy students. Am J Pharm Educ. Volume 79, Issue 7, 2015: Article 106.

*Laverty,G., Gilmore,B.F., Jones,D.S., Coyle,L., Folan,M., Breathnach,R (2015) Antimicrobial Efficacy of an Innovative Emulsion of Medium Chain Triglycerides against Canine and Feline Periodontopathogens. Journal of Small Animal Practice. 56 (4): 253-263.

*Laverty,G., Gorman,S.P., Gilmore,B.F (2015). Biofilm Eradication Kinetics of the Ultrashort Lipopeptide C12-OOWW-NH2 Utilizing a Modified MBEC assay™. Chemical Biology and Drug Design. 85 (5): 645–652.

*Laverty,G., McCloskey,A.P., Gilmore,B.F., Jones,D.S., Zhou,J., Xu,B (2014). Ultrashort Cationic Naphthalene derived Self-assembled Peptides as Antimicrobial Nanomaterials. Biomacromolecules 15; 3429-3439.

Laverty,G., Alkawareek,M., *Gilmore,B.F (2014). The In Vitro Susceptibility of Biofilm Forming Medical Device Related Pathogens to Conventional Antibiotics. Dataset Papers in Science. vol. 2014, Article ID 250694 doi:10.1155/2014/250694.

*Laverty,G., Gilmore,B.F (2014). Cationic Antimicrobial Peptide Cytotoxicity. SOJ Microbiology& Infectious Diseases 2(1): 1-8.

*Hanna,L.A., Barry,J., Donnelly,R., Hughes,F., Jones,D.S., Laverty,G., Parsons,C., Ryan,C. (2014). Utilization of debate as a pedagogical tool for pharmacy students to learn about ethical issues. Am J Pharm Educ. 78 (3): 57.

Alkawareek,M., Algwari,Q.T., Laverty,G., Gorman,S.P., Graham,W.P., O’Connell,D., *Gilmore,B.F (2012). Eradication of Pseudomonas aeruginosa Biofilms by Atmospheric Pressure Non-Thermal Plasma. PLoS ONE 7(8): e44289. doi:10.1371/journal.pone.0044289

Laverty,G., Gorman,S.P., *Gilmore,B.F (2012). The Adherence of Staphylococcus epidermidis to Antimicrobial Peptide Incorporated poly(2-hydroxyethyl methacrylate) Hydrogels. Journal of Biomedical Materials Research: Part A 100A; 1803–1814.

Laverty,G., McLaughlin,M., Shaw,C., Gorman,S.P., *Gilmore,B.F (2010). Antimicrobial Activity of Short, Synthetic Cationic Lipopeptides. Chemical Biology and Drug Design 75 (6); 563-569.

Busetti,A., Crawford,D.E., Earle,M.J., Gilea,M.A., Gilmore,B.F., Gorman,S.P., Laverty,G., Lowry,A.F., McLaughlin,M., Seddon, K.R. (2010) Antimicrobial and antibiofilm activities of 1-alkylquinolinium bromide ionic liquids. Green Chemistry 12; 420 - 425.

Review Papers/Book Chapters

*Laverty,G., An,Y., Pentlavalli,S (2024). Unlocking innovative hydrogel treatments. European Pharmaceutical Review. 2024, 1, 37-39.

Protein-like hydrogels, synthesis, and applications in biomedicine (2024). *Laverty, G. Book title: Hydrogels in Drug Delivery. Eds. Paredes A.J, Larraneta E, Laverty G and Donnelly, R.F. Elsevier.

Antimicrobial peptide nanomaterials (2023). Coulter, S.M., *Laverty, G. Book title: Peptide Bionanomaterials from design to application. Eds. Elsawy, M.A. Springer.

Cross,E.R., Coulter,S.M., Pentlavalli,S., *Laverty,G (2021). Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives. 2021 Soft Matter Emerging Investigators. Soft Matter. 17; 8001-8021; doi.org/10.1039/D1SM00839K

Pentlavalli S, Coulter SM, Laverty G.Peptide nanomaterials for drug delivery applications. Current Protein and Peptide Science, 2020. 21, 4, 401 - 412. DOI : 10.2174/1389203721666200101091834

Hydrogels: Design, synthesis & application in drug delivery & regenerative medicine (2018) Eds. Thakur, R, Laverty, G and Donnelly, R. CRC Press.

Stimuli-responsive biomolecular hydrogels for medical applications (2018). *Laverty,G. Book title: Hydrogels: Design, synthesis & application in drug delivery & regenerative medicine. Eds. Thakur, R, Laverty, G and Donnelly, R. CRC Press.

Antimicrobial peptides as hydrogels for tissue regeneration and repair (2017). *Laverty,G. Book title: Peptides and proteins as biomaterials for tissue regeneration and repair. Eds. Barbosa, M. A and Martins, C. Elsevier.

Rafferty,J., Nagaraj, H., McCloskey,A., Albadr, A., Huwaitat,R., Porter,S., *Laverty,G (2016) Peptide therapeutics and the pharmaceutical industry: barriers encountered translating from the laboratory to patients. Current Medicinal Chemistry. 23(37): 4231-4259

Huwaitat,R., McCloskey,A., Gilmore,B.F., *Laverty,G (2016). Potential strategies for the eradication of multi-drug resistant Gram-negative bacterial infections. Future Microbiology. 11(7); 955-972. DOI 10.2217/fmb-2016-0035.

McCloskey,A., Gilmore,B.F., *Laverty,G (2014). Evolution of Antimicrobial Peptides to Self-assembled Peptides for Biomaterial Applications. Pathogens. 3(4); 791-821

*Laverty,G., Gorman,S.P., Gilmore,B.F (2014). Biomolecular Mechanisms of Pseudomonas aeruginosa and Escherichia coli Biofilm Formation. Pathogens. 3(3); 596-632

Biofilms and Implant-Associated Infections (2014). *Laverty,G., Gorman,S.P., Gilmore, B.F. Book title: Biomaterials and Medical Device Associated Infections. Woodhead Publishing Ltd.

*Laverty,G., Gorman,S.P., Gilmore,B.F. (2013) Biomolecular mechanisms of Staphylococcal Biofilm Formation. Future Microbiology. 8(4); 509-24.

Characteristics and Treatment of Medical Device Associated Infections (2012). *Laverty,G,. Gilmore,B.F. Book title: Advances in Medicine and Biology. Volume 51.Nova Science Publishers.

*Laverty,G., Gorman,S.P., Gilmore,B.F (2011). Antimicrobial Peptides as Biocides. International Journal of Molecular Sciences 12 (10); 6566-6596.

Most recent conference presentations/invited talks

Using neutrons to design, develop and understand the properties of long-acting peptide hydrogel drug delivery platforms for HIV/AIDs. Invited talk. STFC ISIS UK Roadshow, Belfast, N. Ireland, 27th October 2024.

Peptide hydrogels as a long-acting injectable implant for combined HIV/AIDS-contraceptive drug delivery. 10 years of Peptide Materials Meeting, Sorrento, Italy, 26th – 28th October 2023.

Peptide hydrogels as an injectable multipurpose platform for sustained HIV/AIDS-contraceptive drug delivery. Invited talk. Annual Meeting of the Controlled Release Society, Las Vegas USA, 24th – 27th July 2023.

Laverty, G. Long-acting in situ forming peptide hydrogel implants for HIV/AIDS drug delivery. 17th Royal Society of Chemistry Biomaterials Chemistry Group Meeting, Sheffield, UK. 9th – 11th January 2023.

Laverty, G. Enzyme-Responsive Peptide Hydrogels as Long-Acting Injectable Implants for HIV/AIDS Prevention. American Association of Pharmaceutical Scientists (AAPS) 2022 PHARMSCI 360, Boston, USA. 16th-19th October 2022.

Laverty, G. Understanding the microscopic properties and drug diffusion kinetics in long-acting peptide hydrogel drug delivery implants for HIV/AIDs. Plenary talk. Joint ESS ILL User Meeting, Lund, Sweden. 5th – 7th October 2022.

An, Y., Coulter, S.M., Pentlavalli,S., Cross, E.R., Vora, L., Schweins, R., Laverty, G.,* (2022) Long-acting injectable D and L-α peptide hydrogels for HIV/AIDS treatment and prevention. UK Young Macro Group Meeting 2022, University of Nottingham 18th July 2022.

Laverty, G. Peptide Hydrogel & Nanotubes for Drug Delivery and Biomaterial Applications. Invited talk. Researcher Live! Peptide therapeutics: disease screening and drug design - episode 14th July 2022.

Laverty, G. Long-acting injectable peptide-like hydrogel for sustained delivery of drugs. Invited talk. Partnership Opportunities in Drug Delivery, Boston (Virtual attendance) 28th October 2021.

Stimuli-responsive multifunctional peptide-mimetic hydrogels for biomaterial applications. Controlled Release Society Annual Meeting (Virtual) July 2021.

Peptide nanomaterials: The future of drug delivery and biomaterials. Invited talk, key speaker. 12th Global Drug Delivery & Formulation Virtual Summit 2021, 17th March 2021.

An ultrashort multifunctional peptide hydrogel as a novel matrix for chronic wound healing. Controlled Release Society Annual Meeting (Virtual) June 2020.

Peptide-mimetic hydrogels as long-acting injectable implants for the delivery of antiretroviral drugs for HIV/AIDS. Royal Society of Chemistry Biomaterial Chemistry Meeting 2020, University of Manchester, January 2020.

Self-assembling peptide-mimetic hydrogels as long-acting delivery platforms for HIV prevention. Society for Applied Microbiology (Sfam) Early Career Scientist Research Symposium 2019 - Pendulum Hotel, Manchester, England. March 2019.

Optimising phenylalanine-phenylalanine peptide nanotubes to demonstrate selective antibiofilm activity. 8th International Meeting on Antimicrobial Peptides. Surgeons' Hall, Edinburgh, Scotland. September 2018.

Modifying short phenylalanine-phenylalanine peptide sequences to create multifunctional nanomaterials with biomaterial and drug delivery applications. European Peptide Symposium 2018 (EPS 2018). Dublin City University, Ireland, September 2018.

Multifunctional peptide nanomaterials: The future of drug delivery. China Medical University, Shenyang, China. September 2017.

Multifunctional ultrashort antimicrobial peptide nanomaterials for biomedical applications. 13th International Conference on Materials Chemistry (MC13). ACC Liverpool, UK, July 2017.

Ultrashort Self-assembled Peptides for Biomaterial Applications. PepMat 2016. Oral presentation. Universitat Politècnica Catalunya, UPC, Barcelona March 2016.

Ultrashort self-assembling peptidomimetic nanomaterials target resistant pathogenic infections. Oral presentation. Royal Society of Chemistry, London, 5th International Meeting on Antimicrobial Peptides September 2015.

Eradication of Resistant Biofilm Forming Medical Device Related Pathogens by Ultrashort Self-assembled Peptide Nanomaterials. Nanopeptide 2015. Oral presentation. University of Strathclyde, Glasgow, 3rd March 2015.

Ultrashort Cationic Self-assembled Peptide Nanomaterials: A Solution to the Biofilm Crisis? The Academy of Pharmaceutical Sciences GB, UK PharmSci. Oral presentation. University of Hertfordshire, Hatfield, 8th September 2014.

Ultrashort Cationic Self-assembled Peptides/Peptidomimetic Nanomaterials. Northern Ireland Biomedical Engineering Society Symposium. Oral presentation. Riddel Hall, Queen’s University Belfast, May 2014.

Ultrashort Cationic Self-assembled Peptides for the Prevention of Medical Device Related Infection. Poster presentation. All-Ireland Schools of Pharmacy Research Seminar, Trinity College Dublin, April 2014.

Antibiofilm Activities of Ultrashort Antimicrobial Lipopeptides and Self-assembled Ultrashort Peptide Gels. Royal Society of Chemistry, London, 3rd International Meeting on Antimicrobial Peptides September 2013.