Latest hydrogel work published in Chemical Communications
Our latest collaborative work on entitled “Tuning the antimicrobial activity of low molecular weight hydrogels using dopamine autoxidation,” has been accepted within Chemical Communications.
Thanks again to all those involved!
Abstract: We present a method to trigger the formation of dipeptide-based hydrogels by the simple addition of dopamine. Dopamine undergoes oxidation in air, reducing the pH to induce gelation. The production of polydopamine and release of reactive oxygen species such as hydrogen peroxide confers antimicrobial activity. Gel stiffness can be controlled by modulating the initial starting pH of the gelator solution. We can use this method to tune the antimicrobial activity of the gels, with gels that are less stiff demonstrating increased bactericidal efficacy against Gram-positive bacteria.
Advanced Science News Coverage and Advanced Healthcare Materials paper
Our recent research into using peptide hydrogels as long-acting injectable implants for HIV/AIDS drug delivery has be covered by Advanced Science News. This provides an oversight of our most recent publication within Advanced Healthcare Materials. A link to both can be found below: Advanced Science News Advanced Healthcare Materials
Our EPSRC research selected as case study
Our research into long-acting peptide hydrogel drug delivery implants has been selected as a case study by the EPSRC for their Developing New Therapies Grand Challenge. Thanks to all of those involved in this multidisciplinary project and it’s great to see our work moving forward towards future use in patients. Please find a link to the […]
ISIS UK Science Roadshow in Belfast, 27 March 2024
We will be presenting our neutron scattering work and how we use these exciting methods to characterise our peptide drug delivery systems at the ISIS 40th Science Roadshow in Belfast . This forms part of a series of events throughout 2024 with programmes that are intended to cover a diverse range of scientific interests and […]
Get your tickets for the NI Science Festival: Gel Jabs: How Pioneering Hydrogels Fight Infection and Disease
We will be presenting a talk on how we are researching our peptide hydrogels as future medicines at the NI Science Saturday on 25th February 2023 (11 – 12pm) in Lecture Theatre 2, Medical Biology Centre (Queen’s University Belfast, 97 Lisburn Road, Belfast, BT9 7BL). Click here to get your tickets All are welcome to this […]